ABSTRACT
OBJECTIVE@#To provide the evidence of the relationship between brain injury and the time of injury.@*METHODS@#Rats were contused on brain by fluid percussion, then were killed after injury for 15 min, 30 min, 1,3,6,12 h, and 1,4,7,14 d respectively. The expression of caspase-8 were detected by immunohistochemical technology on rat brain section and the results were assessed by image analysis system in the cerebral cortex, thalamus, and hippocampus.@*RESULTS@#The expression of caspase-8 in cortex and hippocampus could be detected in 30 min after injury, increased significantly in 3h, reached apex in 1d after injury, remained 4d before decreased. In addition, the expression of caspase-8 can be detected in 1h after injury and reached apex in 1d after injury, and remained 4d then reduced.@*CONCLUSION@#It seems that the expression of caspase-8 should be a useful target for diagnosis of early brain injury.
Subject(s)
Animals , Male , Rats , Brain Injuries/pathology , Caspase 8/analysis , Cerebral Cortex/pathology , Disease Models, Animal , Head Injuries, Closed/pathology , Hippocampus/pathology , Image Processing, Computer-Assisted , Immunohistochemistry , Random Allocation , Rats, Wistar , Staining and Labeling , Thalamus/pathology , Time FactorsABSTRACT
<p><b>OBJECTIVE</b>To scrutinize the epidemiological characteristics of assaultive injuries in Sichuan province, China.</p><p><b>METHODS</b>A survey of all cases of assaultive injuries reported by police was performed during 8 years in eight counties of Sichuan province, China. A total of 2862 victims and 2856 offenders were registered.</p><p><b>RESULTS</b>The majority of victims and offenders were young men at the age of 20-39 and only received an education at secondary school or primary school. The largest fraction of these cases took place at farm or by-place during 10.00-11.00 o'clock, 16.00-17.00 o'clock and 20.00-21.00 o'clock. The tangles caused by trifles were the most common factors inducing assaultive injuries and accounted for 42.1 percent of the causes of assaults. Blunt injuries were mainly caused by punching (40%) and kicking (17.2%). About 37.3% of the lesions seriously happened in the regions of face and head. Open wounds accounted for 40.3% of these different injuries.</p><p><b>CONCLUSIONS</b>It is valuable to take some specific measures to prevent and control assaultive injuries according to their territorial characteristics.</p>
ABSTRACT
Calcitonin gene-related peptide (CGRP) play a key role in some physiological and pathological progresses. The latest studies indicate that CGRP might involve in some disease progress and has a close relation with wound healing. It is significant to further investigate and then apply it to clinical diagnosis and therapy as well as forensic pathology.